By RICHARD
نویسندگان
چکیده
Major histocompatibility complex (MHC) 1 genes, in particular those encoded in the I region of the murine H-2, have been shown to be of functional importance in several aspects of immune response regulation. Thus, I region-encoded immune response (It) genes determine responsiveness or unresponsiveness to a number of antigens (1); and T cell recognition of I region gene products is critical for the H-2 restricted cell interactions that mediate a number of immune responses (2-6). Although these I region gene functions are well established, the precise identification of the gene products mediating these functions remains uncertain. In contrast, there exists a class of I region gene products, the Ia antigens, for which extensive serologic and biochemical characterization has been accomplished (7-9). The functional role of Ia antigens in immune responses remains undetermined, however, and has been a subject of wide speculation. The present report represents an at tempt to assess the functional significance of Ia antigens in the regulation of antibody responses studied in vitro. A system of primary in vitro antibody responses has been characterized in which responses to soluble trinitrophenyl (TNP)-protein conjugates require the cooperation of T cells, B cells, and accessory cells (6). In these responses, a strict requirement has previously been demonstrated for helper T cell recognition of K or L A encoded determinants expressed on accessory cells (6, 10). In the present studies, the functional role of serologically defined cell surface Ia antigens has been investigated. Using Iaspecific serologic reagents as probes, the present study demonstrates that: (a) a monoclonal anti-Ia reagent specific for a product of I-A k is capable of inhibiting antibody responses in vitro; and that (b) such inhibition occurs at the level of an I-A k product expressed by accessory cells. Moreover, (c) inhibition by this anti-Ia reagent occurs only for responses in which the I-A product on accessory cells is actively recognized by helper T cells as self; and (d) for Ir gene controlled responses, inhibition of response occurs only if the anti-I-A k reagent is directed against determinants
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تاریخ انتشار 2003